Endocrine Abstracts

Introduction: Although pituitary adenomas are considered benign, some have invasive growth, which is one indicator of aggressiveness. Early prognostic markers of aggressiveness may influence the quality of life improvement in patients with aggressive pituitary adenomasObjectives: To study the clinical-immunological, molecular-genetic aspects of aggressive pituitary adenomas and to develop new approaches to early diagnosis and treatment.<p class="abst...

Transsphenoidal pituitary surgery is the method of choice in the treatment of ACTH-DCS, although to date, according to a number of researchers, the method is not ideal. Despite the achievement of immediate postoperative remission in 69-98% of cases, with an increase in the duration of follow-up after TSS from 5 to 10 years, an increase in the frequency of relapses from 15 to 66% is observed. In this regard, we analyzed cases of ACTH DCS subjected to TSS for 2003-2021, included...

The purpose of the study is to study the prognostic role of NT¬proBNP in patients with diabetes mellitus type 2 associated chronic heart failure (CHF).Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 Group a...

The purpose of the study is to study the clinical and hormonal features of diabetes mellitus 2 (DM) associated chronic heart failure (CHF).Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 gr. are patients with DM...

The purpose of the study is to assess the quality of life of patients with autoimmune polyglandular type 2 syndrome using the questionnaire.Material and research methods: Under our observation there were the following 2 groups of patients: 1 gr. - patients with PAI with AIT (primary adrenal insufficiency and autoimmune thyroid) - 25 patients, 2 gr. - PAI with DM 1 (type 1 diabetes mellitus type 1 - 30 patients, as well as 20 healthy pers...

The purpose of the study is to assess the quality of life of patients with autoimmune polyglandular type 2 syndrome using the questionnaire.Material and research methods: Under our observation there were the following 2 groups of patients: 1 gr. - patients with APS with AIT (primary adrenal insufficiency and autoimmune thyroiditis) - 25 patients, 2 gr. - APS with DM 1 (type 1 diabetes mellitus type 1 - 30 patients, as well as 20 healthy persons of the ap...

Objectives: To study the relationship between hyperprolactinemia and various forms of breast cancer in women of fertile age.Methods and materials: The study included 100 breast cancer patients, aged 25 to 43 years (mean age 34.5 &pm; 1.4 years). The patients were divided into 2 groups: Group I 33 patients with hyperprolactinemia, which corresponded to 33%. Group II 67 patients with breast cancer without hyperprolactinemia, which corresponded to 67%. Clin...

Objective: To create a national register of prolactin-secreting pituitary adenomas to assess the prevalence of various forms and the effectiveness of therapy.Material and research methods: National register of patients with pituitary prolactinomas in the Republic of Uzbekistan, includes 172 cases with pituitary prolactinomas, of which 61% (105 women) and 37.2% (64 men), aged 17-74 years, mean age 38.5 &pm; 12.6 years and 3 (1.7%) children and adolescents...

The purpose of the study: Is to study features of cardiovascular complications in patients with Cushing syndrome in the Republic of Uzbekistan (RUz).Material and research methods: In the period of 2002 to 2021, 317 patients were installed with the following clinical forms of Cushing syndrome (CS): 1) ACTH-dependent CS (ACTH-DCS) - 258 (81.3%) patients, of which women -174 (54.8%), men - 84 (26.4%), 2) ACTH independent CS (ACTH-iCS) -51 patients (16.08%) ...

Target: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to T&Rcy;&Acy; for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - 8...